Chiefs vs Colts Week 3 Picks and Predictions: Mahomes Picks Apart Indy's Scheme

The Kansas City Chiefs took care of business last week with a 27-24 win over the Los Angeles Chargers, and now set their sights on an Indianapolis Colts team that has yet to win in 2022.

The Colts have had a horrendous start to the season, first tying in Week 1 with the Houston Texans and then following that up by being on the receiving end of a 24-0 beatdown courtesy of the Jacksonville Jaguars. Needless to say, starting off a playoff-hopeful season with those performances against two lowly franchises is less than ideal.

Can the Colts bounce back in a big way from the confines of Lucas Oil Stadium in their first home game of the season, or will Andy Reid have a bag of tricks up his sleeve on a long week of preparation following the Chiefs’ Thursday night triumph?

Find out in our NFL picks and predictions for Chiefs vs. Colts on Sunday, September 25.

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